Invited Speakers

Geneviève Almouzni

Geneviève Almouzni

Lucia Altucci

Lucia Altucci

Pilar Blancafort

Pilar Blancafort

Tiziana Bonaldi

Tiziana Bonaldi

Maria Carmo-Fonseca

Maria Carmo-Fonseca

Toni Cathomen

Toni Cathomen

Jonathan Chubb

Jonathan Chubb

Luciano de Croce

Luciano de Croce

Martin Fussenegger

Martin Fussenegger

Wouter de Laat

Wouter de Laat

Massimo Loda

Massimo Loda

Luca Magnani

Luca Magnani

Pamela Munster

Pamela Munster

Christoph Plass

Christoph Plass

Maria Rodriguez Martinez

Maria Rodriguez Martinez

Paola Scaffidi

Paola Scaffidi

Vahid Shahrezaei

Vahid Shahrezaei

Henk Stunnenberg

Henk Stunnenberg

Lodewyk Wessels

Lodewyk Wessels

We have invited a core of 20 mainly established investigators and speakers with demonstrated excellent speaker capacities providing an attractive advertisement for our conference. We have carefully selected these invited/keynote speakers to cover the full spectrum of relevant topics in the field taking speaker’s gender into account.

The following speakers have accepted to speak at the meeting:

Keynote speakers:

 Invited speakers:

  • Lucia Altucci, Institute of Genetics and Biophysics, IT
  • Pilar Blancafort, University of Western Australia, AU
  • Tiziana Bonaldi, European Institute of Oncology, SRSI, IT
  • Maria Carmo-Fonseca, Instituto de Medicina Molecular Lisbon, PT
  • Toni Cathomen, University Medical Center Freiburg, DE
  • Luciano Di Croce, Centre for Genomic Regulation, ES
  • Wouter de Laat, Hubrecht Institute, NL
  • Massimo Loda, Harvard Cancer Center, US
  • Luca Magnani, Imperial College London, GB
  • Christoph Plass, German Cancer Research Center, DE
  • Maria Rodriguez Martinez, IBM Research, CH
  • Paola Scaffidi, Francis Crick institute London, GB
  • Vahid Shahrezaei, Imperial College London, GB
  • Henk Stunnenberg, Radboud University Nijmegen, NL
  • Lodewyk Wessels, Netherlands Cancer Institute, NL

Geneviève Almouzni

Structure and function of dynamic chromatin organization


Lucia Altucci

 

 

Università della Campania Luigi Vanvitelli, Dept. Biochimica Biofisica e Patologia Generale, MD, PhD; Specialisation in medical Oncology Full Professor of General Pathology &Rector’s delegate for Research & Innovation University of Campania Luigi Vanvitelli, Naples, IT.

Prof. Geneviève Almouzni is Director of the Cancer Research Center Institut Curie, Paris (FR). She is head of the Nuclear Dynamics and Genome plasticity unit and group leader of the chromatin dynamics team. She obtained her PhD at Pierre-et-Marie-Curie University (FR), worked as postdoctoral fellow at the National Institutes of Health Research Center in Bethesda (USA) in the lab of Prof. Alan Wolffe. She has been CNRS Research Director since January 2000. In 2013, she was awarded the FEBS | EMBO Women in Science Award. She was scientific coordinator of the EU Network of Excellence EpiGeneSys.


Pilar Blancafort

 

 


Tiziana Bonaldi

 

 


Maria Carmo-Fonseca

 

 


Toni Cathomen

Molecular mechanisms governing cell differentiation and cancer processes

Toni Cathomen is Professor of Cell and Gene Therapy and Director of the Institute for Transfusion Medicine and Gene Therapy at the Medical Center of the University of Freiburg, Germany. His research activities focus on the development of disease models and cell therapies based on induced pluripotent stem cells (iPSCs), the improvement of the effectiveness and safety of designer nucleases (CRISPR-Cas and TALEN) for targeted genome editing in clinically relevant human cells, and the development of immune cell therapies (CAR-T cells) for the treatment of various types of tumors.

 


Jonathan Chubb

 

Implications of transcriptional mechanism for cell decision-making

Prof. Jonathan Chubb is a Welcome Senior Fellow at the MRC Laboratory for Molecular Cell Biology, University College London. His group would like to understand how cells make choices about their fates.  To achieve this, they take the view that one needs to observe the gene expression of individual cells before and during the decision-making process, to test how initial cell "state" maps onto final cell fate.  In particular, his group develop and use approaches to image the transcription of genes in living cells.


Luciano di Croce

 

Molecular mechanisms governing cell differentiation and cancer processes

Since its formation, Di Croce’s group has focused its research efforts on understanding how epigenetic modifications and chromatin changes are established and, once in place, how they affect gene expression, cell differentiation and transformation.

Polycomb and MLL/Trithorax complexes are evolutionarily conserved chromatin-modifying factors originally identified as part of an epigenetic cellular memory system that maintains repressed or active gene expression states. Recent data indicate that they regulate a plethora of cellular processes, including X chromosome inactivation, genomic imprinting, cell cycle control, stem cell biology, and cancer. Polycomb proteins form at least two distinct complexes: the Polycomb-repressive complexes 1 and 2 (PRC1 and PRC2), both possessing histone-modifying enzymatic activities resulting in monoubiquitination at lysine 119 of histone H2A and methylation at lysine 27 of histone H3, respectively. The catalytic activity and the binding of Polycomb to its genomic sites can be modulated by associated factors. The antagonistic function is performed by MLL complexes that trough deposition of methyl marks on lysine 4 of histone H3 positively regulate transcription, thus counteracting the activity of Polycomb complexes. I will discuss how Polycomb and MLL proteins (including novel associated factors) impact on transcription, genome architecture, and their role in stem cell biology.


Martin Fussenegger

 

 


Wouter de Laat

 

 


Massimo Loda

 

 


Luca Magnani

 

 

Luca Magnani has trained in Italy and the US before starting his laboratory at Imperial College London. His background is in epigenetics. He has a strong interest in translational science, with a strong focus and breast cancer. He is currently supported by a CRUK career development fellowship and EU grants. His laboratory studies how tumors evolve in response to therapy using genomics and epigenomics. His multi-disciplinary team consist of a medics, biologists and computational biologists and uses and develops cutting-edge approaches to study breast cancer evolution.


Pamela Munster

 

 


Christoph Plass

 

 

 

 


Maria Rodriguez Martinez

 

 

Dr. María Rodríguez Martínez is the technical lead of the group of Systems Biology at IBM Research - Zürich. A physicist by training, she did her PhD and a first postdoc in High Energy Physics at the Institut d’Astrophysique de Paris and Hebrew University respectively. In 2006, she transitioned into Systems Biology as a postdoc at the Weizmann Institute of Science and later at Columbia University. Since 2013 she is a member of the Systems Biology group at IBM Research – Zürich, and an associated member of the Department of Biology at ETH since 2014. Her current research focuses on the development of computational and statistical approaches to unravel cancer molecular mechanisms using high-throughput multi-omics datasets and single-cell molecular data.


Paola Scaffidi

 

Epigenetics mechanisms of tumour maintenance

Paola Scaffidi obtained her PhD from the Open University of London, working at the San Raffaele Institute in Milan, Italy. She then moved to the US National Cancer Institute to work in Tom Misteli's laboratory, first as a postdoctoral fellow and then as a staff scientist. She joined the Cancer Research UK London Research Institute (LRI) in 2014 to lead the Cancer Epigenetics Laboratory. In 2015, the LRI became part of the Francis Crick Institute.


Vahid Shahrezaei

 

 

Vahid Shahrezaei has done his PhD in Physics at Simon Fraser University, postdoc at McGill University and is a reader in biomathematics at Imperial college London. He is also Mathematician in residence at MRC London Institute in Medical Sciences. He uses mathematical and statistical approaches to study temporal, spatial and stochastic dynamics of biochemical networks inside cells using single cell and global biological data. His work on modelling intrinsic and extrinsic noise in gene expression is highly cited.


Henk Stunnenberg

 

 

Henk Stunnenberg is full professor and head of the Department of Molecular Biology of the Radboud University and the Radboud Medical Centre.
He obtained his PhD in Genetics at the University of Wageningen (NL) and after a post-doc at the University of Zürich (CH), he fulfilled positions as group leader at Hoffmann-LaRoche (CH) and at the Gene Expression Program at EMBL (Heidelberg, DE). He is a member of EMBO since 1994.
Professor Stunnenberg is coordinator of the EU FP7 High Impact Project BLUEPRINT (the BLUEPRINT of Haematopoietic Epigenomes) that runs from 2011-2016 and currently he is Chair of the International Scientific Steering Committee of the International Human Epigenome Consortium (IHEC). In 2013 he received an ERC Advanced Grant of € 2.5 million for his project ‘SysStemCell’.

 

 

L.F.A. Wessels

Integrative modeling for precision medicine

Lodewyk Wessels is the head of the Computational Cancer Biology group at the Netherlands Cancer Institute. His group focuses on quantifying and understanding treatment response in model systems and patients. To end they develop besproke and novel computational methods focusing on data integration and tailored to new technologies. Lodewyk Wessels holds a chair in Computational Cancer Biology at the Delft University of Technology and serves as Deputy Director Research of the Nehters Cancer Institute.